R&D and Technology Transfer: Firm-Level Evidence from Chinese Industry

The capacity of developing economies to narrow the gap in living standards with the OECD nations depends critically on their ability to imitate and innovate new technologies. Toward this end, developing economies have access to three avenues of technological advance: technology transfer, domestic R&D, and foreign direct investment. This paper examines the contributions of each of these avenues, as well as their interactions, to productivity and knowledge production within Chinese industry. Based on a large data set for China’s large and medium-size enterprises, the estimation results show that technology transfer – whether domestic or foreign – affects productivity only through its interactions with in-house R&D. Foreign direct investment does not appear to facilitate the adoption of market-mediated foreign technology transfer. Firms wishing to produce patentable knowledge do not benefit from technology transfer; patentable knowledge is created exclusively through in-house R&D operations.http://deepblue.lib.umich.edu/bitstream/2027.42/39968/3/wp582.pd

Experimental and numerical study on self-sustaining performance of a 30-kW micro gas turbine generator system during startup process

The safe startup of micro gas turbine (MGT) generator system is the premise of normal operation. The whole start-up process contains motor startup, ignition, speed acceleration, motor switching to generator and power acceleration. Motor switching to generator happens at the self-sustaining state, which is significant to safe start-up process. However, characteristics of MGT generator system at self-sustaining state are hardly to investigate due to the lack of performance maps and complete experiments. Therefore, this work analyzed start-up schedule and presented a theoretical and experimental study on the self-sustaining performance of MGT generator system, based on the self-designed 30 kW MGT generator system built in Jiangjin Turbocharger Plant, China. The self-sustaining speed boundary and fuel consumption area is determined from the aspects of safe startup. A novel principle for determining the self-sustaining point (SSP) is proposed. Results show that the self-sustaining state can be achieved only when speed is over 26,750 rpm, and the SSP is determined at the speed of 30,750 rpm based on the proposed principle. Finally, the self-sustaining TIT and natural gas flow are compared with the experimental data, with two relative errors both almost within 4%. This method is instructive to the MGT generator system startup process

Spontaneous imbibition behavior in porous media with various hydraulic fracture propagations: A pore-scale perspective

Hydraulic fracturing technology can improve the geologic structure of unconventional oil and gas reservoirs, yielding a complex fracture network resulting from the synergistic action of hydraulic and natural fractures. However, the impact of spontaneous imbibition associated with hydraulic fracture propagation on the reservoir matrix remains poorly understood. In this study, combining the Cahn-Hilliard phase field method with the Navier-Stokes equations, pore-scale modeling was employed to capture the evolution of the oil-water interface during dynamic spontaneous imbibition for hydraulic fracture propagation in a two-end open mode. This pore-scale modeling approach can effectively circumvent the challenges of conducting spontaneous imbibition experiments on specimens partitioned by hydraulic fractures. A direct correlation was established between the pressure difference curve and the morphology of discharged oil phase in the primary hydraulic fracture, providing valuable insights into the distribution of oil phase in spontaneous imbibition. Furthermore, it was shown that secondary hydraulic fracture propagation expands the longitudinal swept area and enhances the utilization of natural fractures in the transverse swept area during spontaneous imbibition. When secondary hydraulic fracture propagation results in the interconnection of upper and lower primary hydraulic fractures, competitive imbibition occurs in the matrix, leading to reduced oil recovery compared to the unconnected models. Our results shed light upon the spontaneous imbibition mechanism in porous media with hydraulic fracture propagation, contributing to the refinement and application of hydraulic fracturing techniques.Document Type: Original articleCited as: Zhou, Y., Guan, W., Zhao, C., Zou, X., He, Z., Zhao, H. Spontaneous imbibition behavior in porous media with various hydraulic fracture propagations: A pore-scale perspective. Advances in Geo-Energy Research, 2023, 9(3): 185-197. https://doi.org/10.46690/ager.2023.09.0

Dictionary learning sparse-sampling reconstruction method for in-vivo 3D photoacoustic computed tomography

The sparse transforms currently used in the model-based reconstruction method for photoacoustic computed tomography (PACT) are predefined and they typically cannot capture the underlying features of the specific data sets adequately, thus limiting the high-quality recovery of photoacoustic images. In this work, we present an advanced reconstruction model using the K-VSD dictionary learning technique and present the in vivo results after adapting the model into the 3D PACT system. The in vivo experiments were performed on an IRB approved human hand and two rats. When compared to the traditional sparse transform, experimental results using our proposed method improved accuracy and contrast to noise ration of the reconstructed photoacoustic images, on average, by 3.7 and 1.8 times in the case of 50% sparse-sampling rate, respectively. We also compared the performance of our algorithm against other techniques, and imaging speed was 60% faster than other approaches. Our system would require sparse-transducer array and lower number of data acquisition hardware (DAQs) potentially reducing the cost of the system. Thus, our work provides a new way for reconstructing photoacoustic images, and it would enable the development of new high-speed low-cost 3D PACT for various biomedical applications

CNP Promotes Antiarrhythmic Effects via Phosphodiesterase 2

Background: Ventricular arrhythmia and sudden cardiac death are the most common lethal complications after myocardial infarction. Antiarrhythmic pharmacotherapy remains a clinical challenge and novel concepts are highly desired. Here, we focus on the cardioprotective CNP (C-type natriuretic peptide) as a novel antiarrhythmic principle. We hypothesize that antiarrhythmic effects of CNP are mediated by PDE2 (phosphodiesterase 2), which has the unique property to be stimulated by cGMP to primarily hydrolyze cAMP. Thus, CNP might promote beneficial effects of PDE2-mediated negative crosstalk between cAMP and cGMP signaling pathways. Methods: To determine antiarrhythmic effects of cGMP-mediated PDE2 stimulation by CNP, we analyzed arrhythmic events and intracellular trigger mechanisms in mice in vivo, at organ level and in isolated cardiomyocytes as well as in human-induced pluripotent stem cell-derived cardiomyocytes. Results: In ex vivo perfused mouse hearts, CNP abrogated arrhythmia after ischemia/reperfusion injury. Upon high-dose catecholamine injections in mice, PDE2 inhibition prevented the antiarrhythmic effect of CNP. In mouse ventricular cardiomyocytes, CNP blunted the catecholamine-mediated increase in arrhythmogenic events as well as in ICaL, INaL, and Ca2+spark frequency. Mechanistically, this was driven by reduced cellular cAMP levels and decreased phosphorylation of Ca2+handling proteins. Key experiments were confirmed in human iPSC-derived cardiomyocytes. Accordingly, the protective CNP effects were reversed by either specific pharmacological PDE2 inhibition or cardiomyocyte-specific PDE2 deletion. Conclusions: CNP shows strong PDE2-dependent antiarrhythmic effects. Consequently, the CNP-PDE2 axis represents a novel and attractive target for future antiarrhythmic strategies

Salusin-α Inhibits Proliferation and Migration of Vascular Smooth Muscle Cell via Akt/mTOR Signaling

Background/Aims: The proliferation and migration of vascular smooth muscle cells (VSMCs) are key steps in the progression of atherosclerosis. The aim of the present study was to investigate the potential roles of salusin-α in the functions of VSMCs during the development of atherosclerosis. Methods: In vivo, the effects of salusin-α on atherogenesis were examined in rabbits fed a cholesterol diet. The aortas were en face stained with Sudan IV to evaluate the gross atherosclerotic lesion size. The cellular components of atherosclerotic plaques were analyzed by immunohistochemical methods. In vitro, Cell Counting Kit-8 and wound-healing assays were used to assess the effects of salusin-α on VSMC proliferation and migration. In addition, western blotting was used to evaluate the total and phosphorylated levels of Akt (also known as protein kinase B) and mammalian target of rapamycin (mTOR) in VSMCs. Results: Salusin-α infusion significantly reduced the aortic lesion areas of atherosclerosis, with a 39% reduction in the aortic arch, a 71% reduction in the thoracic aorta, and a 71% reduction in the abdominal aorta; plasma lipid levels were unaffected. Immunohistochemical staining showed that salusin-α decreased both macrophage- and VSMC-positively stained areas in atherosclerotic lesions by 54% and 69%, cell proliferative activity in the intima and media of arteriosclerotic lesions, and matrix metalloproteinase 2 (MMP-2) and MMP-9 expression in plaques. Studies using cultured VSMCs showed that salusin-α decreased VSMC migration and proliferation via reduced phosphorylation of Akt and mTOR. Conclusion: Our data indicate that salusin-α suppresses the development of atherosclerosis by inhibiting VSMC proliferation and migration through the Akt/mTOR pathway

A White Paper on Broadband Connectivity in 6G

Executive Summary This white paper explores the road to implementing broadband connectivity in future 6G wireless systems. Different categories of use cases are considered, from extreme capacity with peak data rates up to 1 Tbps, to raising the typical data rates by orders-of-magnitude, to support broadband connectivity at railway speeds up to 1000 km/h. To achieve these goals, not only the terrestrial networks will be evolved but they will also be integrated with satellite networks, all facilitating autonomous systems and various interconnected structures. We believe that several categories of enablers at the infrastructure, spectrum, and protocol/algorithmic levels are required to realize the intended broadband connectivity goals in 6G. At the infrastructure level, we consider ultra-massive MIMO technology (possibly implemented using holographic radio), intelligent reflecting surfaces, user-centric and scalable cell-free networking, integrated access and backhaul, and integrated space and terrestrial networks. At the spectrum level, the network must seamlessly utilize sub-6 GHz bands for coverage and spatial multiplexing of many devices, while higher bands will be used for pushing the peak rates of point-to-point links. The latter path will lead to THz communications complemented by visible light communications in specific scenarios. At the protocol/algorithmic level, the enablers include improved coding, modulation, and waveforms to achieve lower latencies, higher reliability, and reduced complexity. Different options will be needed to optimally support different use cases. The resource efficiency can be further improved by using various combinations of full-duplex radios, interference management based on rate-splitting, machine-learning-based optimization, coded caching, and broadcasting. Finally, the three levels of enablers must be utilized not only to deliver better broadband services in urban areas, but also to provide full-coverage broadband connectivity must be one of the key outcomes of 6G

Insight-HXMT observations of Swift J0243.6+6124 during its 2017-2018 outburst

The recently discovered neutron star transient Swift J0243.6+6124 has been monitored by {\it the Hard X-ray Modulation Telescope} ({\it Insight-\rm HXMT). Based on the obtained data, we investigate the broadband spectrum of the source throughout the outburst. We estimate the broadband flux of the source and search for possible cyclotron line in the broadband spectrum. No evidence of line-like features is, however, found up to $\rm 150~keV$. In the absence of any cyclotron line in its energy spectrum, we estimate the magnetic field of the source based on the observed spin evolution of the neutron star by applying two accretion torque models. In both cases, we get consistent results with $B\rm \sim 10^{13}~G$, $D\rm \sim 6~kpc$ and peak luminosity of $\rm >10^{39}~erg~s^{-1}$ which makes the source the first Galactic ultraluminous X-ray source hosting a neutron star.Comment: publishe